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KMID : 1009020200180020203
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Clinical Psychopharmacology and Neuroscience
2020 Volume.18 No. 2 p.203 ~ p.213
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Vitamin D Supplementation is Beneficial for Children with Autism Spectrum Disorder: A Meta-analysis
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Song Liyao
Luo Xiaomei
Jiang Qing
Chen Zhi
Zhou Lifang
Wang Dan
Chen Ai
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Abstract
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Objective: We conducted a meta-analysis of randomized controlled trials to explore whether vitamin D supplementation is beneficial for symptom improvement in children with autism spectrum disorder.
Methods: We systematically searched the PubMed database, EMBASE, Cochrane Library, Web of Science, Sino-Med, Wanfang Data, and China National Knowledge Infrastructure mainly up to September 2019. Using a fixed effects model, we calculated the standard mean difference with 95% confidence interval. Furthermore, we analyzed baseline serum 25-hydroxyvitamin D levels and outcome scores including the Social Responsiveness Scale and Child Autism Rating Scale scores after vitamin D supplementation.
Results: There was no significant difference in baseline serum 25-hydroxyvitamin D levels among 203 children included from three studies in the meta-analysis. After vitamin D supplementation, the outcome scores in the experimental group were dramatically elevated compared with those in the control group (p = 0.03).
Conclusion: Vitamin D supplementation improves the typical symptoms of autism spectrum disorder, as indicated by reduced Social Responsiveness Scale and Child Autism Rating Scale scores; thus, it is beneficial for children with autism spectrum disorder.
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KEYWORD
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Vitamin D, Children, Autism spectrum disorder, Meta-analysis
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